Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL
نویسندگان
چکیده
منابع مشابه
Molecular profiling in CLL.
Chronic lymphocytic leukemia (CLL) has an extremely heterogeneous clinical course, with some patients requiring immediate therapy and others living without need for treatment for decades. There has been considerable interest in the underlying molecular mechanisms of this heterogeneity to understand not only the expected clinical course for individual patients but also the underlying pathogenesi...
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Management and outcome of patients with CLL have changed during the past decade due to improvements in molecular diagnostics and the implementation of targeted drug therapy.2,3 This rapid progress was due to the discovery of chromosomal changes, the understanding of the prognostic impact of the mutational status of immunoglobulin heavy chain genes, the discovery of prognostic markers and potent...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2019
ISSN: 1552-4450,1552-4469
DOI: 10.1038/s41589-018-0205-2